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CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice

Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis.However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure.Here, we find increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cul

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